Mutagenicity of Aromatic Amines and Azaheterocyclic Compounds
نویسندگان
چکیده
منابع مشابه
Quantum-chemical studies on mutagenicity of aromatic and heteroaromatic amines.
Arylamines are well-known as widespread industrial and environmental mutagens and carcinogens. Their bioactivity stems from enzymatic metabolic activation to reactive and highly electrophilic intermediates. In this work, computational investigations related to the biological activity of these compounds have been reviewed, especially focusing on studies reporting results from quantum-mechanical ...
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Aromatic amines are prevalently used in a wide variety of industries and are ubiquitous in foods and environment. Many of this class of compounds are potentially mutagenic or even carcinogenic, and the assessment and prediction of their mutagenicity are of practical importance because mutagenicity and carcinogenicity are toxicological end points that play major roles in the genesis of cancer an...
متن کاملModification of plasmid and bacteriophage DNA by aromatic amines: effects on survival, template activity, and mutagenicity.
The carcinogenic and mutagenic effects of the aromatic amines are believed to depend on their covalent modification of DNA, primarily through the formation of adducts at C8 of guanine. The actual biologic and biochemical responses to these adducts can be envisioned as the consequence of the abilities of the cell to repair the lesions, with or without fidelity, and the introduction of errors thr...
متن کاملNitrosamines and Aromatic Amines
A new method for the simultaneous determination of hemoglobin adducts from aromatic amines and tobacco-specific nitrosamines (TSNA) is described. After mild base-catalysed hydrolysis releasing aromatic amines and the TSNA adduct 4-hydroxy-1-(3-pyridyl)-1butanone (HPB), the extraction, cleanup, and concentration are performed by a one-step procedure using C 1 8 cartridges. Determination in the p...
متن کاملInhibition of the mutagenicity of aromatic amines by the plant flavonoid (+)-catechin.
Addition of the plant phenolic flavonoid (+)-catechin to rat liver microsomes inhibited the mutagenicity of the aromatic amines 2-aminofluorene and 4-aminobiphenyl in the Ames test. Similarly, (+)-catechin decreased the mutagenicity of N-hydroxy-4-amino-biphenyl, the proximate carcinogen, but, in contrast, had no effect on the mutagenicity of other direct-acting carcinogens such as N-methyl-N'-...
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ژورنال
عنوان ژورنال: Sangyo Igaku
سال: 1981
ISSN: 0047-1879,1881-1302
DOI: 10.1539/joh1959.23.7_762_2